K.A.S. and M.S.M. contributed equally to this work. We thank Don Mahuran and Michael Tropak for their generous gift of human HEXA and HEXB, Rosemary Cornell for the HPTLC plates, and Cara-Lynne Schengrund for useful discussions on the use of SK-N-SH cells and HPTLC of gangliosides. This work was supported by a grant from the Natural Sciences and Engineering Research Council of Canada (NSERC). D.J.V. is a scholar of the Michael Smith Foundation of Health Research (MSFHR) and a Tier II Canada Research Chair in Chemical Glycobiology. K.A.S. is supported by a Discovery project grant from the Australian Research Council. M.S.M. is a recipient of a senior scholarship from the NSERC and MSFHR.
A Selective Inhibitor Gal-PUGNAc of Human Lysosomal β-Hexosaminidases Modulates Levels of the Ganglioside GM2 in Neuroblastoma Cells†
Article first published online: 7 JAN 2009
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 7, pages 1300–1303, February 2, 2009
How to Cite
Stubbs, Keith A., Macauley, Matthew S. and Vocadlo, David J. (2009), A Selective Inhibitor Gal-PUGNAc of Human Lysosomal β-Hexosaminidases Modulates Levels of the Ganglioside GM2 in Neuroblastoma Cells. Angew. Chem. Int. Ed., 48: 1300–1303. doi: 10.1002/anie.200804583
- Issue published online: 28 JAN 2009
- Article first published online: 7 JAN 2009
- Manuscript Received: 17 SEP 2008
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Michael Smith Foundation of Health Research (MSFHR)
- Australian Research Council
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