Dynamic Combinatorial Evolution within Self-Replicating Supramolecular Assemblies

Authors

  • Rémi Nguyen,

    1. SAMS Laboratory—icFRC—Université de Strasbourg—Institut Charles Sadron, CNRS—UPR 22, 23 rue du Loess, BP 84047, 67034 Strasbourg cedex 2 (France), Fax: (+33) 3-8841-4099
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  • Lionel Allouche Dr.,

    1. Institut de Chimie, Service de RMN, Université Louis Pasteur, 1 rue Blaise Pascal, 67008 Strasbourg cedex (France)
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  • Eric Buhler Prof. Dr.,

    1. Matière et Systèmes Complexes Laboratory, Université Paris-VII, UMR 7057, 10 rue Alice Domon et Léonie Duquet, 75205 Paris cedex 13 (France)
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  • Nicolas Giuseppone Prof. Dr.

    1. SAMS Laboratory—icFRC—Université de Strasbourg—Institut Charles Sadron, CNRS—UPR 22, 23 rue du Loess, BP 84047, 67034 Strasbourg cedex 2 (France), Fax: (+33) 3-8841-4099
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  • We thank the CNRS, the icFRC (RTRA), and the University Louis Pasteur for financial support. This work was supported by a doctoral fellowship of the Région Alsace (R.N.). We also acknowledge ESF-COST System Chemistry action.

Abstract

original image

Survival of the fittest: Self-assemblies made of dynamic block copolymers (dynablocks) can self-replicate by catalyzing the formation of their own building blocks. Moreover, in competition experiments, the differential thermodynamic stabilities and autocatalytic efficiencies of these self-assemblies lead to sigmoid growth of the most efficient self-replicator and to depletion of its competitors.

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