Communication

High-Purity Discrete PEG-Oligomer Crystals Allow Structural Insight†

  1. Alister C. French,
  2. Amber L. Thompson Dr.,
  3. Benjamin G. Davis Prof.

Article first published online: 13 JAN 2009

DOI: 10.1002/anie.200804623

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 7, pages 1248–1252, February 2, 2009

Additional Information

How to Cite

French, Alister C., Thompson, Amber L. and Davis, Benjamin G. (2009), High-Purity Discrete PEG-Oligomer Crystals Allow Structural Insight. Angew. Chem. Int. Ed., 48: 1248–1252. doi: 10.1002/anie.200804623

Author Information

  1. Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford (UK), Fax: (+44) 1865-275-674 users.ox.ac.uk/ndplb0149

  1. †

    We thank Drs. John Porter and Mike Eaton from UCB-Celltech for invaluable collaborative support; Dr. David J. Watkin for crystallographic insight and CEM for their generosity and technical support. UCB-Celltech and the BBSRC funded an Industrial CASE Studentship for A.C.F. PEG=Poly(ethylene glycol).

Publication History

  1. Issue published online: 28 JAN 2009
  2. Article first published online: 13 JAN 2009
  3. Manuscript Received: 20 SEP 2008

Funded by

  • UCB-Celltech
  • BBSRC
  • Industrial CASE Studentship

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Keywords:

  • helical structures;
  • mass spectrometry;
  • poly(ethylene glycol);
  • polymers;
  • synthetic methods

Abstract

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To great (monodisperse) lengths: An improved synthesis of purer ethylene glycol (EG) oligomers allows access to 16- and 32-mers pure enough for multiple incorporation, and also to the longest (48-mer) discrete EG oligomer yet reported. The high purity enables the first crystallizations and hence the first glimpses of secondary 310-helical PEG structures.

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