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We are grateful to Prof. Seiichiro Himeno of this institute for kind advice on determining Hg content. This study was financially supported by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of the Japanese Government, and MEXT-HITEC.
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Silaphenylmercuric Triflate Catalyzed Reactions: Synthesis of a Solid-Supported Mercuric Salt Catalyst†
Article first published online: 9 JAN 2009
DOI: 10.1002/anie.200804641
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Yamamoto, H., Sasaki, I., Hirai, Y., Namba, K., Imagawa, H. and Nishizawa, M. (2009), Silaphenylmercuric Triflate Catalyzed Reactions: Synthesis of a Solid-Supported Mercuric Salt Catalyst. Angew. Chem. Int. Ed., 48: 1244–1247. doi: 10.1002/anie.200804641
- †
Publication History
- Issue published online: 28 JAN 2009
- Article first published online: 9 JAN 2009
- Manuscript Revised: 29 NOV 2008
- Manuscript Received: 22 SEP 2008
Funded by
- Ministry of Education, Culture, Sports, Science, and Technology
- MEXT-HITEC
Keywords:
- alkynes;
- cyclization;
- flow reactor;
- heterocycles;
- mercury
Abstract
Let it flow, let it flow: A procedure to generate the first solid-supported mercuric salt, silaphenylmercuric triflate, is described. Silaphenylmercuric triflate showed remarkable catalytic activity for an indole synthesis, furanoyne cyclization, arylyne cyclization, and tandem carbocyclizations. An efficient flow reaction system for indole synthesis and arylyne cyclization is also described (see figure).