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Stabilization of an α Helix by β-Sheet-Mediated Self-Assembly of a Macrocyclic Peptide


  • This work was supported by the National Creative Research Initiative Program of the Ministry of Education, Science and Technology.


Protein roll call: Peptide-based building blocks, in which both an α-helix-forming segment and a β-sheet segment are located within a single macrocyclic structure, self-assemble into α-helix-decorated artificial proteins. This approach provides a starting point for developing artificial proteins that can modulate α-helix-mediated interactions occurring in a multivalent fashion.

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