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Palladium-Catalyzed Annulation of Acyloximes with Arynes (or Alkynes): Synthesis of Phenanthridines and Isoquinolines


  • Financial support from CNRS and the Institut de Chimie des Substances Naturelles are gratefully acknowledged. T.G. thanks the institute for a doctoral fellowships.


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Intermolecular insertion: A palladium-catalyzed domino aminopalladation/ C[BOND]H functionalization sequence has been developed, and provides access to functionalized phenanthridines and isoquinolines (see scheme; Tf=triflate, TMS=trimethylsilyl, M.S.=molecular sieves). The use of butyronitrile as the solvent is determinant to the success of the domino process.