Communication

A Selective Fluoroionophore Based on BODIPY-functionalized Magnetic Silica Nanoparticles: Removal of Pb2+ from Human Blood†

  1. Hye Young Lee1,
  2. Doo Ri Bae1,
  3. Ji Chan Park2,
  4. Hyunjoon Song Prof.2,
  5. Won Seok Han Dr.1,
  6. Jong Hwa Jung Prof.1

Article first published online: 7 JAN 2009

DOI: 10.1002/anie.200804714

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 7, pages 1239–1243, February 2, 2009

Additional Information

How to Cite

Lee, H., Bae, D., Park, J., Song, H., Han, W. and Jung, J. (2009), A Selective Fluoroionophore Based on BODIPY-functionalized Magnetic Silica Nanoparticles: Removal of Pb2+ from Human Blood. Angew. Chem. Int. Ed., 48: 1239–1243. doi: 10.1002/anie.200804714

Author Information

  1. 1

    Department of Chemistry and Research Institute of Natural Sciences and Environmental Biotechnology National Core Research Center, Gyeongsang National University, Jinju 660-701 (Korea), Fax: (+82) 55-758-6027

  2. 2

    Department of Chemistry and School of Molecular Science, Korea Advanced Institute of Science and Technology, Daejeon 305-701 (Korea)

  1. †

    This work was supported by a grant from the EB-NCRC (grant no. R15-2003-012-01001-0) and (grant no. R01-2007-000-20299-0) supported by the KSEF/MOST of Korea. BODIPY=4,4-difluoro-4-bora-3a,4a-diaza-s-indacene.

Publication History

  1. Issue published online: 28 JAN 2009
  2. Article first published online: 7 JAN 2009
  3. Manuscript Revised: 10 DEC 2008
  4. Manuscript Received: 26 SEP 2008

Funded by

  • EB-NCRC. Grant Numbers: R15-2003-012-01001-0, R01-2007-000-20299-0
  • KSEF/MOST

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Keywords:

  • blood;
  • chemosensors;
  • fluorescence;
  • lead;
  • nanoparticles

Abstract

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Get the lead out: The title fluorescence receptor exhibits a high affinity and selectivity for Pb2+ over competing metal ions in water (see picture) with an overall emission change of approximately 8-fold at the emission maximum for Pb2+. The fluorescence receptor can remove 96 % of 100 ppb Pb2+ from human blood, and can be useful and effective for the selective and rapid removal of Pb2+ in vivo.

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