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A Selective Fluoroionophore Based on BODIPY-functionalized Magnetic Silica Nanoparticles: Removal of Pb2+ from Human Blood

Authors

  • Hye Young Lee,

    1. Department of Chemistry and Research Institute of Natural Sciences and Environmental Biotechnology National Core Research Center, Gyeongsang National University, Jinju 660-701 (Korea), Fax: (+82) 55-758-6027
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  • Doo Ri Bae,

    1. Department of Chemistry and Research Institute of Natural Sciences and Environmental Biotechnology National Core Research Center, Gyeongsang National University, Jinju 660-701 (Korea), Fax: (+82) 55-758-6027
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  • Ji Chan Park,

    1. Department of Chemistry and School of Molecular Science, Korea Advanced Institute of Science and Technology, Daejeon 305-701 (Korea)
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  • Hyunjoon Song Prof.,

    1. Department of Chemistry and School of Molecular Science, Korea Advanced Institute of Science and Technology, Daejeon 305-701 (Korea)
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  • Won Seok Han Dr.,

    1. Department of Chemistry and Research Institute of Natural Sciences and Environmental Biotechnology National Core Research Center, Gyeongsang National University, Jinju 660-701 (Korea), Fax: (+82) 55-758-6027
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  • Jong Hwa Jung Prof.

    1. Department of Chemistry and Research Institute of Natural Sciences and Environmental Biotechnology National Core Research Center, Gyeongsang National University, Jinju 660-701 (Korea), Fax: (+82) 55-758-6027
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  • This work was supported by a grant from the EB-NCRC (grant no. R15-2003-012-01001-0) and (grant no. R01-2007-000-20299-0) supported by the KSEF/MOST of Korea. BODIPY=4,4-difluoro-4-bora-3a,4a-diaza-s-indacene.

Abstract

Get the lead out: The title fluorescence receptor exhibits a high affinity and selectivity for Pb2+ over competing metal ions in water (see picture) with an overall emission change of approximately 8-fold at the emission maximum for Pb2+. The fluorescence receptor can remove 96 % of 100 ppb Pb2+ from human blood, and can be useful and effective for the selective and rapid removal of Pb2+ in vivo.

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