This work was supported by the Swiss National Science Foundation (SNF) and the ETH Zurich
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Communication
Catalyzed Dehydrogenative Coupling of Primary Alcohols with Water, Methanol, or Amines†
Article first published online: 12 DEC 2008
DOI: 10.1002/anie.200804757
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Zweifel, T., Naubron, J.-V. and Grützmacher, H. (2009), Catalyzed Dehydrogenative Coupling of Primary Alcohols with Water, Methanol, or Amines. Angew. Chem. Int. Ed., 48: 559–563. doi: 10.1002/anie.200804757
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Publication History
- Issue published online: 29 DEC 2008
- Article first published online: 12 DEC 2008
- Manuscript Received: 29 SEP 2008
Funded by
- National Science Foundation (SNF)
- ETH Zurich
Keywords:
- alcohols;
- amines;
- density functional calculations;
- homogeneous catalysis;
- rhodium
A working partnership: Metal–ligand cooperativity is responsible for the high activity of the rhodium amido complex 1 in the dehydrogenative coupling of primary alcohols with water, methanol, or amines, including ammonia (see scheme), to give carboxylic acids, methyl carboxylates, or amides, respectively. The catalysis proceeds under mild reaction conditions in the presence of a recyclable hydrogen acceptor A. The multistep mechanism was elucidated by computational methods.