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Catalyzed Dehydrogenative Coupling of Primary Alcohols with Water, Methanol, or Amines


  • This work was supported by the Swiss National Science Foundation (SNF) and the ETH Zurich


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A working partnership: Metal–ligand cooperativity is responsible for the high activity of the rhodium amido complex 1 in the dehydrogenative coupling of primary alcohols with water, methanol, or amines, including ammonia (see scheme), to give carboxylic acids, methyl carboxylates, or amides, respectively. The catalysis proceeds under mild reaction conditions in the presence of a recyclable hydrogen acceptor A. The multistep mechanism was elucidated by computational methods.