A cunning and dangerous plan foiled! An enzyme-specific molecular construct exploits the overexpression of β-lactamase in several drug-resistant bacteria. Specific photodynamic toxicity was detected towards β-lactam-resistant methicillin-resistant Staphylococcus aureus (MRSA), whereby the usual mechanism for antibiotic resistance (cleavage of the β-lactam ring) releases the phototoxic component from the prodrug (see picture; Q=quencher).
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