Benzofurans Prepared by C[BOND]H Bond Functionalization with Acylsilanes


  • Financial support was provided by the University of Toronto, the Canadian Foundation for Innovation, Ontario Research Foundation, NSERC, and Boehringer Ingelheim.


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Instant carbenes—that's hot: The thermal 1,2-Brook rearrangement of acylsilanes generates siloxycarbene intermediates that can undergo intramolecular C[BOND]H bond insertion to provide benzofuran derivatives. This metal-free tandem reaction occurs in less than 10 minutes in the microwave.