We thank the National Science Council of the Republic of China (NSC 96-2113M-007-020-MY3) for support of this research.
A Cooperative Copper- and Palladium-Catalyzed Three-Component Coupling of Benzynes, Allylic Epoxides, and Terminal Alkynes†
Article first published online: 3 DEC 2008
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 2, pages 391–394, January 2, 2009
How to Cite
Jeganmohan, M., Bhuvaneswari, S. and Cheng, C.-H. (2009), A Cooperative Copper- and Palladium-Catalyzed Three-Component Coupling of Benzynes, Allylic Epoxides, and Terminal Alkynes. Angew. Chem. Int. Ed., 48: 391–394. doi: 10.1002/anie.200804873
- Issue published online: 22 DEC 2008
- Article first published online: 3 DEC 2008
- Manuscript Received: 6 OCT 2008
- National Science Council of the Republic of China. Grant Number: NSC 96-2113M-007-020-MY3
A little cooperation: A cooperative copper- and palladium-catalyzed highly regio- and chemoselective three-component coupling of benzynes, allylic epoxides, and terminal alkynes provides an efficient atom-economical route to ortho-disubstituted arenes. The resulting product undergoes a gold-catalyzed cyclization reaction (see scheme; dba=dibenzylideneacetone, dppp=1,3-bis(diphenylphosphanyl)propane).