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A Cooperative Copper- and Palladium-Catalyzed Three-Component Coupling of Benzynes, Allylic Epoxides, and Terminal Alkynes


  • We thank the National Science Council of the Republic of China (NSC 96-2113M-007-020-MY3) for support of this research.


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A little cooperation: A cooperative copper- and palladium-catalyzed highly regio- and chemoselective three-component coupling of benzynes, allylic epoxides, and terminal alkynes provides an efficient atom-economical route to ortho-disubstituted arenes. The resulting product undergoes a gold-catalyzed cyclization reaction (see scheme; dba=dibenzylideneacetone, dppp=1,3-bis(diphenylphosphanyl)propane).