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This work was supported in part by Grant-in-Aid for Creative Scientific Research from The Ministry of Education, Culture, Sports, Science, and Technology (MEXT).
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Communication
High-Yielding Synthesis of the Anti-Influenza Neuramidase Inhibitor (−)-Oseltamivir by Three “One-Pot” Operations†
Article first published online: 2 JAN 2009
DOI: 10.1002/anie.200804883
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Ishikawa, H., Suzuki, T. and Hayashi, Y. (2009), High-Yielding Synthesis of the Anti-Influenza Neuramidase Inhibitor (−)-Oseltamivir by Three “One-Pot” Operations. Angewandte Chemie International Edition, 48: 1304–1307. doi: 10.1002/anie.200804883
- †
Publication History
- Issue published online: 28 JAN 2009
- Article first published online: 2 JAN 2009
- Manuscript Received: 6 OCT 2008
Funded by
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT)
Keywords:
- antiviral agents;
- domino reactions;
- organocatalysis;
- oseltamivir;
- Tamiflu
Graphical Abstract
Taking shortcuts: A remarkably short and high-yielding asymmetric total synthesis of (−)-oseltamivir takes advantage of organocatalysis and single-pot domino operations. The target, known as the drug Tamiflu, is prepared efficiently in a short time, and also its derivatives can be synthesized effectively.
Abstract
Taking shortcuts: A remarkably short and high-yielding asymmetric total synthesis of (−)-oseltamivir takes advantage of organocatalysis and single-pot domino operations. The target, known as the drug Tamiflu, is prepared efficiently in a short time, and also its derivatives can be synthesized effectively.