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High-Yielding Synthesis of the Anti-Influenza Neuramidase Inhibitor (−)-Oseltamivir by Three “One-Pot” Operations


  • This work was supported in part by Grant-in-Aid for Creative Scientific Research from The Ministry of Education, Culture, Sports, Science, and Technology (MEXT).


Taking shortcuts: A remarkably short and high-yielding asymmetric total synthesis of (−)-oseltamivir takes advantage of organocatalysis and single-pot domino operations. The target, known as the drug Tamiflu, is prepared efficiently in a short time, and also its derivatives can be synthesized effectively.

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