Practical Imidazole-Based Phosphine Ligands for Selective Palladium-Catalyzed Hydroxylation of Aryl Halides

Authors


  • We thank Dr. W. Baumann, Dr. C. Fischer, A. Koch, S. Buchholz, S. Schareina, A. Kammer, and S. Rossmeisl for excellent analytical support. We gratefully acknowledge Evonik (formerly Degussa) for financial support.

Abstract

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The phenol countdown: Novel imidazole-based phosphine ligands are synthesized on scales up to 100 g by a convenient lithiation–phosphorylation method. The phosphines are stable towards air and moisture and are successfully applied as ligands in the palladium-catalyzed selective hydroxylation of aryl halides (see scheme, dba=dibenzylideneacetone).

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