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Metal-Ion Selectivity of Chemically Modified Uracil Pairs in DNA Duplexes


  • This work was supported in part by grants-in-aids for Scientific Research (B) (16350090), and the “Scientific Frontier” Project (2006-2011) from MEXT (Japan). We thank Prof. H. Torigoe, Prof. Y. Tanaka, and Dr. T Kurokawa for kind support.


DNA duplexes containing 5-modified uracil pairs (5-bromo, 5-fluoro, and 5-cyanouracil) bind selectivity to metal ions. Their selectivity is sensitive to the pH value of the solution (see picture), as the acidities of the modified uracil bases vary according to the electron-withdrawing properties of the substituents.

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