We thank the Fonds der Chemischen Industrie, the European Research Council for an advanced investigator grant, and the Deutsche Forschungsgemeinschaft (DFG) for financial support. We also thank Evonik AG (Hanau), BASF AG (Ludwigshafen), and Chemetall GmbH (Frankfurt) for the generous gift of chemicals.
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Communication
Aluminum Bases for the Highly Chemoselective Preparation of Aryl and Heteroaryl Aluminum Compounds†
Article first published online: 13 JAN 2009
DOI: 10.1002/anie.200804966
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Wunderlich, Stefan H. and Knochel, P. (2009), Aluminum Bases for the Highly Chemoselective Preparation of Aryl and Heteroaryl Aluminum Compounds. Angew. Chem. Int. Ed., 48: 1501–1504. doi: 10.1002/anie.200804966
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Publication History
- Issue published online: 30 JAN 2009
- Article first published online: 13 JAN 2009
- Manuscript Received: 10 OCT 2008
Funded by
- Fonds der Chemischen Industrie
- European Research Council
- Deutsche Forschungsgemeinschaft (DFG)
Keywords:
- aluminum;
- copper;
- cross-coupling;
- homogeneous catalysis;
- lithium
Abstract
Selective C![[BOND]](http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif)
H activation with a series of neutral aluminum trisamide bases led to a wide range of polyfunctional aryl and heteroaryl aluminum reagents. Ester and cyano groups are stable under the reaction conditions for this direct alumination, and donor oxygen substituents are efficient directing groups. High metalation regioselectivities were observed with O,S and N,S heterocycles (see example).