Bifunctional Dendrimers: From Robust Synthesis and Accelerated One-Pot Postfunctionalization Strategy to Potential Applications

Authors

  • Per Antoni Dr.,

    1. Royal Institute of Technology, School of Chemistry and Chemical Science, Division of Coating Technology, Teknikringen 56-58, 10044 Stockholm (Sweden), Fax: (+46) 790-8283
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  • Yvonne Hed,

    1. Royal Institute of Technology, School of Chemistry and Chemical Science, Division of Coating Technology, Teknikringen 56-58, 10044 Stockholm (Sweden), Fax: (+46) 790-8283
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  • Axel Nordberg,

    1. Royal Institute of Technology, School of Technology and Health, Neuronic Engineering, Huddinge (Sweden) and Karolinska Institute, Department of Clinical Neuroscience, Stockholm (Sweden)
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  • Daniel Nyström Dr.,

    1. Royal Institute of Technology, School of Chemistry and Chemical Science, Division of Coating Technology, Teknikringen 56-58, 10044 Stockholm (Sweden), Fax: (+46) 790-8283
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  • Hans von Holst Prof.,

    1. Royal Institute of Technology, School of Technology and Health, Neuronic Engineering, Huddinge (Sweden) and Karolinska Institute, Department of Clinical Neuroscience, Stockholm (Sweden)
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  • Anders Hult Prof.,

    1. Royal Institute of Technology, School of Chemistry and Chemical Science, Division of Coating Technology, Teknikringen 56-58, 10044 Stockholm (Sweden), Fax: (+46) 790-8283
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  • Michael Malkoch Prof.

    1. Royal Institute of Technology, School of Chemistry and Chemical Science, Division of Coating Technology, Teknikringen 56-58, 10044 Stockholm (Sweden), Fax: (+46) 790-8283
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  • We thank the Swedish Research Council (VR) Grant 2006-3617.

Abstract

A fourth wheel: Two sets of bifunctional AB2C dendrimers having internal acetylene/azides and external hydroxy groups were constructed utilizing benign synthetic protocols. An in situ postfunctionalization strategy was successfully carried out to illustrate the chemoselective nature of these dendrimers. The dendrimers were also transformed into dendritic nanoparticles or utilized as dendritic crosslinkers for the fabrication hydrogels.

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