This work was supported by the National Institutes of Health (GM58832) and the China Scholarship Council. Mass spectrometry was provided by the Washington University Mass Spectrometry Resource, an NIH Research Resource (Grant P41RR0954).
Efficient Synthesis of Chiral β-Arylisopropylamines by Using Catalytic Asymmetric Hydrogenation†
Article first published online: 19 DEC 2008
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 4, pages 800–802, January 12, 2009
How to Cite
Chen, J., Zhang, W., Geng, H., Li, W., Hou, G., Lei, A. and Zhang, X. (2009), Efficient Synthesis of Chiral β-Arylisopropylamines by Using Catalytic Asymmetric Hydrogenation. Angew. Chem. Int. Ed., 48: 800–802. doi: 10.1002/anie.200805058
- Issue published online: 5 JAN 2009
- Article first published online: 19 DEC 2008
- Manuscript Received: 16 OCT 2008
- National Institutes of Health. Grant Number: GM58832
- China Scholarship Council
- NIH. Grant Number: P41RR0954
- drug design;
Direct condensation of β-arylketones with acetamide afforded both Z and E enamides. The Z-configured substrates underwent hydrogenation with excellent enantioselectivity by using the Rh/tangphos catalytic system (see scheme; tangphos=1,1′-di-tert-butyl-[2,2′]-diphospholanyl). The product β-arylisopropylamines are important precursors to several drugs.