Enantioselective Synthesis of P-Stereogenic Phosphinates and Phosphine Oxides by Molybdenum-Catalyzed Asymmetric Ring-Closing Metathesis


  • This research was financially supported by the EPSRC (DTA Award to J.S.H.), the John Fell Fund (062/214), and by the United States National Institutes of Health (GM-59426).


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The first catalytic route toward the title compounds by asymmetric ring-closing metathesis is described. A remarkable reversal of enantioselectivity is observed when the achiral imido ligand of the chiral molybdenum-catalyst is changed (see scheme), thus highlighting the importance of the achiral and the chiral ligands in catalyst design.