Communication

Self-Assembled Bidentate Ligands for the Nickel-Catalyzed Hydrocyanation of Alkenes†

  1. Michiel de Greef Dr.,
  2. Bernhard Breit Prof. Dr.

Article first published online: 12 DEC 2008

DOI: 10.1002/anie.200805092

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 3, pages 551–554, January 5, 2009

Additional Information

How to Cite

de Greef, M. and Breit, B. (2009), Self-Assembled Bidentate Ligands for the Nickel-Catalyzed Hydrocyanation of Alkenes. Angew. Chem. Int. Ed., 48: 551–554. doi: 10.1002/anie.200805092

Author Information

  1. Institut für Organische Chemie und Biochemie, Freiburg Institute for Advanced Studies (FRIAS), Albert-Ludwigs-Universität Freiburg, Albertstrasse 21, 79104 Freiburg i. Brsg. (Germany), Fax: (+49) 761-203-8715

  1. †

    This work was supported by the Alexander von Humboldt-Foundation (fellowship to M.d.G.), the DFG (IRTG 1038) and the Krupp Foundation.

Publication History

  1. Issue published online: 29 DEC 2008
  2. Article first published online: 12 DEC 2008
  3. Manuscript Received: 17 OCT 2008

Funded by

  • DFG. Grant Number: IRTG 1038
  • Krupp Foundation

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Keywords:

  • alkenes;
  • homogeneous catalysis;
  • hydrogen bonding;
  • nickel;
  • self-assembly
Thumbnail image of graphical abstract

Well-stocked library: A catalyst with interesting activity, regioselectivity (rs), and functional-group tolerance could be identified from a 5×4 library of isoquinolone- or aminopyridine-derived self-assembled bidentate ligands. These ligands, which self-assemble through hydrogen bonding, form complexes with nickel(0) that appeared to be promising catalysts for the hydrocyanation of styrene (see scheme).

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