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Self-Assembled Bidentate Ligands for the Nickel-Catalyzed Hydrocyanation of Alkenes

Authors

  • Michiel de Greef Dr.,

    1. Institut für Organische Chemie und Biochemie, Freiburg Institute for Advanced Studies (FRIAS), Albert-Ludwigs-Universität Freiburg, Albertstrasse 21, 79104 Freiburg i. Brsg. (Germany), Fax: (+49) 761-203-8715
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  • Bernhard Breit Prof. Dr.

    1. Institut für Organische Chemie und Biochemie, Freiburg Institute for Advanced Studies (FRIAS), Albert-Ludwigs-Universität Freiburg, Albertstrasse 21, 79104 Freiburg i. Brsg. (Germany), Fax: (+49) 761-203-8715
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  • This work was supported by the Alexander von Humboldt-Foundation (fellowship to M.d.G.), the DFG (IRTG 1038) and the Krupp Foundation.

Abstract

original image

Well-stocked library: A catalyst with interesting activity, regioselectivity (rs), and functional-group tolerance could be identified from a 5×4 library of isoquinolone- or aminopyridine-derived self-assembled bidentate ligands. These ligands, which self-assemble through hydrogen bonding, form complexes with nickel(0) that appeared to be promising catalysts for the hydrocyanation of styrene (see scheme).

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