This work was supported by the California Sea Grant Program (R/NMP-98 to B.S.M.) and by a Ruth L. Kirschstein National Research Service Award to J.M.W. from the NIH Training Program in Marine Biotechnology (GM067550). We thank Dr. W. Fenical, Dr. P. R. Jensen, Dr. H. C. Kwon, and Dr. J. Y. Cho (University of California at San Diego (USA)) for Streptomyces sp. CNQ-766 and standard azamerone, and Dr. R. J. Parry (Rice University (USA)), Dr. T. F. Molinski, Dr. T. A. M. Gulder, and Dr. A. A. Mrse for helpful advice.
Formation of the Pyridazine Natural Product Azamerone by Biosynthetic Rearrangement of an Aryl Diazoketone†
Article first published online: 15 DEC 2008
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 4, pages 767–770, January 12, 2009
How to Cite
Winter, Jaclyn M., Jansma, Ariane L., Handel, Tracy M. and Moore, Bradley S. (2009), Formation of the Pyridazine Natural Product Azamerone by Biosynthetic Rearrangement of an Aryl Diazoketone. Angew. Chem. Int. Ed., 48: 767–770. doi: 10.1002/anie.200805140
- Issue published online: 5 JAN 2009
- Article first published online: 15 DEC 2008
- Manuscript Received: 20 OCT 2008
- California Sea Grant Program. Grant Number: R/NMP-98
- NIH. Grant Number: GM067550
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