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Keywords:

  • cyclization;
  • drug delivery;
  • liposomes;
  • phospholipase;
  • prodrugs

Abstract

Thumbnail image of graphical abstract

Special delivery: Liposomal drug-delivery systems in which prodrugs are activated specifically by disease-associated enzymes have great potential for the treatment of severe diseases, such as cancer. A new type of phospholipid-based prodrug has the ability to form stable small unilamellar vesicles (see picture). Activation of the prodrug vesicles by the enzyme sPLA2 initiates a cyclization reaction, which leads to the release of the drug.