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Keywords:

  • cerium;
  • immunoassays;
  • nanotechnology;
  • oxidases;
  • oxidation

Abstract

Thumbnail image of graphical abstract

Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase-like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification allows both for binding and for detection by the catalytic oxidation of sensitive colorimetric dyes (e.g. TMB).