The authors acknowledge funding by the National Institutes of Health (CA101781) and an UCF-NSTC Start Up Fund, all to J.M.P.
Oxidase-Like Activity of Polymer-Coated Cerium Oxide Nanoparticles†
Article first published online: 7 JAN 2009
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 13, pages 2308–2312, March 16, 2009
How to Cite
Asati, A., Santra, S., Kaittanis, C., Nath, S. and Perez, J. Manuel. (2009), Oxidase-Like Activity of Polymer-Coated Cerium Oxide Nanoparticles. Angew. Chem. Int. Ed., 48: 2308–2312. doi: 10.1002/anie.200805279
- Issue published online: 10 MAR 2009
- Article first published online: 7 JAN 2009
- Manuscript Received: 28 OCT 2008
- National Institutes of Health. Grant Number: CA101781
Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase-like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification allows both for binding and for detection by the catalytic oxidation of sensitive colorimetric dyes (e.g. TMB).