Communication

Oxidase-Like Activity of Polymer-Coated Cerium Oxide Nanoparticles†

  1. Atul Asati,
  2. Santimukul Santra Dr.,
  3. Charalambos Kaittanis,
  4. Sudip Nath Dr.,
  5. J. Manuel Perez Prof.

Article first published online: 7 JAN 2009

DOI: 10.1002/anie.200805279

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 13, pages 2308–2312, March 16, 2009

Additional Information

How to Cite

Asati, A., Santra, S., Kaittanis, C., Nath, S. and Perez, J. Manuel. (2009), Oxidase-Like Activity of Polymer-Coated Cerium Oxide Nanoparticles. Angew. Chem. Int. Ed., 48: 2308–2312. doi: 10.1002/anie.200805279

Author Information

  1. Nanoscience Technology Center, Department of Chemistry and Burnett College of Biomedical Sciences, University of Central Florida, 12424 Research Parkway, Suite 400, Orlando, FL 32826 (USA), Fax: (+1) 407-882-2843 http://www.nanoscience.ucf.edu/faculty/perez.php

  1. †

    The authors acknowledge funding by the National Institutes of Health (CA101781) and an UCF-NSTC Start Up Fund, all to J.M.P.

Publication History

  1. Issue published online: 10 MAR 2009
  2. Article first published online: 7 JAN 2009
  3. Manuscript Received: 28 OCT 2008

Funded by

  • National Institutes of Health. Grant Number: CA101781

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Keywords:

  • cerium;
  • immunoassays;
  • nanotechnology;
  • oxidases;
  • oxidation

Abstract

Thumbnail image of graphical abstract

Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase-like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification allows both for binding and for detection by the catalytic oxidation of sensitive colorimetric dyes (e.g. TMB).

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