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Oxidase-Like Activity of Polymer-Coated Cerium Oxide Nanoparticles

Authors


  • The authors acknowledge funding by the National Institutes of Health (CA101781) and an UCF-NSTC Start Up Fund, all to J.M.P.

Abstract

Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase-like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification allows both for binding and for detection by the catalytic oxidation of sensitive colorimetric dyes (e.g. TMB).

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