These authors contributed equally to this work.
Gold Nanorod/Fe3O4 Nanoparticle “Nano-Pearl-Necklaces” for Simultaneous Targeting, Dual-Mode Imaging, and Photothermal Ablation of Cancer Cells†
Article first published online: 12 MAR 2009
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 15, pages 2759–2763, March 30, 2009
How to Cite
Wang, C., Chen, J., Talavage, T. and Irudayaraj, J. (2009), Gold Nanorod/Fe3O4 Nanoparticle “Nano-Pearl-Necklaces” for Simultaneous Targeting, Dual-Mode Imaging, and Photothermal Ablation of Cancer Cells . Angew. Chem. Int. Ed., 48: 2759–2763. doi: 10.1002/anie.200805282
Part funding of this research from the CFSE-USDA grant is a gratefully acknowledged. A. Wang is acknowledged for providing magnetic nanoparticles from Ocean Nanotech LLC. Dr. Shalev is acknowledged for the temperature device.
- Issue published online: 24 MAR 2009
- Article first published online: 12 MAR 2009
- Manuscript Revised: 20 DEC 2008
- Manuscript Received: 28 OCT 2008
- cell recognition;
- imaging agents;
- photothermal ablation
Gold and pearls: Multifunctional nanoparticles, each composed of a single, amine-modified gold nanorod, decorated with multiple “pearls” of Fe3O4 nanoparticles capped with carboxy groups, are prepared. Their effectiveness in simultaneous targeting, dual-mode imaging, and photothermal ablation of breast cancer cells is demonstrated.