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Keywords:

  • asymmetric synthesis;
  • desymmetrization;
  • natural products;
  • substituted glycerols

Abstract

Thumbnail image of graphical abstract

The quaternary king: Azithromycin (1), which has improved pharmacological profiles compared with erythromycins, was the target of an enantioselective synthesis. All the stereogenic quaternary carbon centers were elaborated by a desymmetrization of 2-substituted glycerols using a chiral imine/CuCl2 catalyst.