Communication

Total Synthesis of Azithromycin†

  1. Hyoung Cheul Kim,
  2. Sung Ho Kang Prof. Dr.

Article first published online: 27 JAN 2009

DOI: 10.1002/anie.200805334

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 10, pages 1827–1829, February 23, 2009

Additional Information

How to Cite

Kim, H. and Kang, S. (2009), Total Synthesis of Azithromycin. Angew. Chem. Int. Ed., 48: 1827–1829. doi: 10.1002/anie.200805334

Author Information

  1. Department of Chemistry, School of Molecular Science (BK21), KAIST, Daejeon 305-701 (Korea), Fax: (+82) 42-350-2810

  1. †

    This work was supported by a Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST; R01-2007-000-10051-0).

Publication History

  1. Issue published online: 17 FEB 2009
  2. Article first published online: 27 JAN 2009
  3. Manuscript Received: 31 OCT 2008

Funded by

  • Korea Science and Engineering Foundation (KOSEF)
  • MOST. Grant Number: R01-2007-000-10051-0

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Keywords:

  • asymmetric synthesis;
  • desymmetrization;
  • natural products;
  • substituted glycerols

Abstract

Thumbnail image of graphical abstract

The quaternary king: Azithromycin (1), which has improved pharmacological profiles compared with erythromycins, was the target of an enantioselective synthesis. All the stereogenic quaternary carbon centers were elaborated by a desymmetrization of 2-substituted glycerols using a chiral imine/CuCl2 catalyst.

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