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Total Synthesis of Azithromycin


  • This work was supported by a Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST; R01-2007-000-10051-0).


The quaternary king: Azithromycin (1), which has improved pharmacological profiles compared with erythromycins, was the target of an enantioselective synthesis. All the stereogenic quaternary carbon centers were elaborated by a desymmetrization of 2-substituted glycerols using a chiral imine/CuCl2 catalyst.

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