Synthesis of Supramolecular Nanocapsules Based on Threading of Multiple Cyclodextrins over Polymers on Gold Nanoparticles


  • We acknowledge the financial support from the Ministry of Education (MOE) Academic Research Fund (AcRF) and Institute of Materials Research and Engineering, Singapore. We would like to thank Prof. K. W. Leong of Duke University and Prof. G. Sukhorukov of Queen Mary, University of London for their valuable discussions and suggestions.


The CD's stuck: Poly(ethylene glycol) chains anchored onto gold nanoparticles (AuNPs) are threaded by multiple α-cyclodextrin (α-CD) rings to form a supramolecular outer layer composed of pseudopolyrotaxane columns perpendicular to the nanoparticle surface. Capping the polymer ends confines α-CD on the nanoparticle surface, cross-linking the α-CD rings and then removing the AuNP cores produces supramolecular nanocapsules.

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