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The European Commission through the project FP7-201431 (CATAFLU.OR), PRIN (Progetto Nazionale Stereoselezioni in Chimica Organica: Metodologie ed Applicazioni) and Bologna University are acknowledged for financial support for this research. We thank Professors C. Melchiorre and M. Roberti for the use of the polarimeter.
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Communication
Organocatalytic Asymmetric Alkylation of Aldehydes by SN1-Type Reaction of Alcohols†
Article first published online: 20 JAN 2009
DOI: 10.1002/anie.200805423
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Cozzi, P., Benfatti, F. and Zoli, L. (2009), Organocatalytic Asymmetric Alkylation of Aldehydes by SN1-Type Reaction of Alcohols. Angew. Chem. Int. Ed., 48: 1313–1316. doi: 10.1002/anie.200805423
- †
Publication History
- Issue published online: 28 JAN 2009
- Article first published online: 20 JAN 2009
- Manuscript Received: 6 NOV 2008
Funded by
- European Commission. Grant Number: FP7-201431
- PRIN
- Bologna University
Keywords:
- alcohols;
- aldehydes;
- carbocations;
- enamines;
- organocatalysis
Abstract
Work-alcoholic! The elusive enantioselective catalytic α-alkylation of aldehydes, a widely sought transformation, was brought to execution by the use of alcohols capable of forming stabilized carbocations (see scheme, TFA=trifluoroacetic acid).