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Organocatalytic Asymmetric Alkylation of Aldehydes by SN1-Type Reaction of Alcohols

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  • The European Commission through the project FP7-201431 (CATAFLU.OR), PRIN (Progetto Nazionale Stereoselezioni in Chimica Organica: Metodologie ed Applicazioni) and Bologna University are acknowledged for financial support for this research. We thank Professors C. Melchiorre and M. Roberti for the use of the polarimeter.

Abstract

Work-alcoholic! The elusive enantioselective catalytic α-alkylation of aldehydes, a widely sought transformation, was brought to execution by the use of alcohols capable of forming stabilized carbocations (see scheme, TFA=trifluoroacetic acid).

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