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Synthesis of Unprecedented Scaffold Diversity
Article first published online: 9 JAN 2009
DOI: 10.1002/anie.200805452
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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How to Cite
Galloway, Warren R. J. D., Diáz-Gavilán, M., Isidro-Llobet, A. and Spring, David R. (2009), Synthesis of Unprecedented Scaffold Diversity. Angew. Chem. Int. Ed., 48: 1194–1196. doi: 10.1002/anie.200805452
Publication History
- Issue published online: 28 JAN 2009
- Article first published online: 9 JAN 2009
- Abstract
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Keywords:
- combinatorial chemistry;
- diversity-oriented synthesis;
- metathesis;
- molecular scaffolds;
- natural products
Abstract
Building a better library: The synthesis of a library of natural-product-like small molecules with unprecedented scaffold diversity has been reported (see scheme; Ns=nosylate). The library represents a significant advancement in the capability of synthetic chemists to generate structurally diverse and complex small molecules in a rapid manner.