Communication

Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor†

  1. Suwei Dong1,
  2. Ernest Hamel Dr.3,
  3. Ruoli Bai Dr.3,
  4. David G. Covell Dr.4,
  5. John A. Beutler Dr.2,
  6. John A. Porco Jr. Prof. Dr.1

Article first published online: 12 JAN 2009

DOI: 10.1002/anie.200805486

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 8, pages 1494–1497, February 9, 2009

Additional Information

How to Cite

Dong, S., Hamel, E., Bai, R., Covell, David G., Beutler, John A. and Porco, John A. (2009), Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor. Angew. Chem. Int. Ed., 48: 1494–1497. doi: 10.1002/anie.200805486

Author Information

  1. 1

    Department of Chemistry, Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, 590 Commonwealth Avenue, Boston, MA 02215 (USA), Fax: (+1) 617-358-2847

  2. 2

    Molecular Targets Development Program, National Cancer Institute at Frederick, MD (USA)

  3. 3

    Toxicology and Pharmacology Branch, National Cancer Institute at Frederick, MD (USA)

  4. 4

    Screening Technologies Branch, Developmental Therapeutics, Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, MD (USA)

  1. †

    Financial support from the National Institutes of Health (GM-073855 and P50 GM067041), Wyeth Pharmaceuticals, Merck Research Laboratories, and the NCI intramural research program is gratefully acknowledged. We thank the Developmental Therapeutics Program at the NCI for the 60-cell assay, ThalesNano, Inc. (Budapest, Hungary) for assistance with the continuous-flow hydrogenation reactor, and Prof. Dr. Corey Stephenson (Boston University) for helpful discussions.

Publication History

  1. Issue published online: 30 JAN 2009
  2. Article first published online: 12 JAN 2009
  3. Manuscript Received: 10 NOV 2008

Funded by

  • National Institutes of Health. Grant Numbers: GM-073855, P50 GM067041
  • Wyeth Pharmaceuticals
  • Merck Research Laboratories

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