SEARCH

SEARCH BY CITATION

Keywords:

  • cyclization;
  • homogeneous catalysis;
  • multicomponent reactions;
  • palladium;
  • spiroacetals

Abstract

Thumbnail image of graphical abstract

Functionalized spiroacetals have been easily prepared in a one-pot three-component coupling process that involves the reaction of pentynol derivatives, salicylaldehydes, and amines in the presence of catalytic amounts of a palladium(II) complex (see scheme). Alternatively, oxygen-substituted spiroacetals can be obtained by using orthoesters as the third component.