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A Palladium(II)-Catalyzed Synthesis of Spiroacetals through a One-Pot Multicomponent Cascade Reaction

Authors

  • José Barluenga Prof. Dr.,

    1. Instituto Universitario de Química Organometálica “Enrique Moles”, Unidad Asociada al C.S.I.C., Universidad de Oviedo, Julián Clavería, 8; 33006 Oviedo (Spain), Fax: (+34) 985103450
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  • Abraham Mendoza,

    1. Instituto Universitario de Química Organometálica “Enrique Moles”, Unidad Asociada al C.S.I.C., Universidad de Oviedo, Julián Clavería, 8; 33006 Oviedo (Spain), Fax: (+34) 985103450
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  • Félix Rodríguez Dr.,

    1. Instituto Universitario de Química Organometálica “Enrique Moles”, Unidad Asociada al C.S.I.C., Universidad de Oviedo, Julián Clavería, 8; 33006 Oviedo (Spain), Fax: (+34) 985103450
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  • Francisco J. Fañanás Dr.

    1. Instituto Universitario de Química Organometálica “Enrique Moles”, Unidad Asociada al C.S.I.C., Universidad de Oviedo, Julián Clavería, 8; 33006 Oviedo (Spain), Fax: (+34) 985103450
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  • We gratefully acknowledge financial support from the DGICYT (CTQ2007-61048/BQU) and the MEC (grant to A.M.)

Abstract

Functionalized spiroacetals have been easily prepared in a one-pot three-component coupling process that involves the reaction of pentynol derivatives, salicylaldehydes, and amines in the presence of catalytic amounts of a palladium(II) complex (see scheme). Alternatively, oxygen-substituted spiroacetals can be obtained by using orthoesters as the third component.

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