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Receptor-Mediated Targeting of Cathepsins in Professional Antigen Presenting Cells


  • We thank the Netherlands Organisation for Scientific Research (NWO), the Netherlands Proteomics Center (NPC), and the Marie Curie Research Training Network (MRTN-CT-2004-512585) for their financial support.


Tag for professionals: A fluorescently tagged clustered mannoside DCG-04 analogue (see structure) is designed and synthesized using a modular approach. Uptake of the probe in professional antigen presenting cells and subsequent labeling of cathepsins proceeded in a mannose-receptor dependent manner.

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