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Keywords:

  • cooperative effects;
  • homogeneous catalysis;
  • nitrogen heterocycles;
  • ring opening;
  • small ring systems

Abstract

Thumbnail image of graphical abstract

Cooperative metal centers in a bimetallic catalyst facilitate the highly enantioselective ring opening of meso aziridines 1 with silyl nucleophiles (see scheme; TMS=trimethylsilyl). The 1,2-azidoamides 2 and 1,2-amidonitriles 3 obtained in this way in high yields and with up to 99 % ee are valuable precursors to enantiomerically pure 1,2-diamines and β-amino acids.