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We thank the C. Eugene Bennett Department of Chemistry, the Eberly College of Arts and Science, the WV Nano Initiative at West Virginia University, and the ACS-PRF for financial support.
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Communication
Enantioselective Intermolecular Crossed-Conjugate Additions between Nitroalkenes and α,β-Enals through a Dual Activation Strategy†
Article first published online: 2 JAN 2009
DOI: 10.1002/anie.200805558
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Zhong, C., Chen, Y., Petersen, Jeffrey L., Akhmedov, Novruz G. and Shi, X. (2009), Enantioselective Intermolecular Crossed-Conjugate Additions between Nitroalkenes and α,β-Enals through a Dual Activation Strategy. Angew. Chem. Int. Ed., 48: 1279–1282. doi: 10.1002/anie.200805558
- †
Publication History
- Issue published online: 28 JAN 2009
- Article first published online: 2 JAN 2009
- Manuscript Received: 14 NOV 2008
Funded by
- C. Eugene Bennett Department of Chemistry
- Eberly College of Arts and Science
- WV Nano Initiative
- ACS-PRF
Keywords:
- asymmetric catalysis;
- enantioselectivity;
- Lewis bases;
- pyrrolidines
Abstract
Double the fun: The title reaction was developed by using a Lewis base/iminium activation strategy (see scheme). The reaction proceeded with excellent yields and ee values, and the products were additionally transformed into a single enantiomer of a substituted pyrrolidine with excellent retention of configuration.