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Enantioselective Intermolecular Crossed-Conjugate Additions between Nitroalkenes and α,β-Enals through a Dual Activation Strategy

Authors


  • We thank the C. Eugene Bennett Department of Chemistry, the Eberly College of Arts and Science, the WV Nano Initiative at West Virginia University, and the ACS-PRF for financial support.

Abstract

Double the fun: The title reaction was developed by using a Lewis base/iminium activation strategy (see scheme). The reaction proceeded with excellent yields and ee values, and the products were additionally transformed into a single enantiomer of a substituted pyrrolidine with excellent retention of configuration.

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