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LiCl-Mediated Preparation of Functionalized Benzylic Indium(III) Halides and Highly Chemoselective Palladium-Catalyzed Cross-Coupling in a Protic Cosolvent


  • Y.-H.C. thanks the Humboldt Foundation for financial support. We thank Dr. Sheng-Kai Wang (The Scripps Research Institute) for valuable suggestions. We thank the Fonds der Chemischen Industrie, the DFG, and the European Research Council (ERC) for financial support. We thank Chemetall for the generous gift of chemicals.


Sensitive functional groups such as COR, CHO, or CH2OH can be present in benzylic indium reagents prepared by the direct insertion of indium in the presence of LiCl. These reagents undergo palladium-catalyzed cross-coupling reactions in the presence of a protic cosolvent after activation with iPrMgCl⋅LiCl (see scheme). Remarkable chemoselectivities are achieved by using various electrophiles containing NH or OH groups.

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