This work was supported by ARC (3365) and EU FP6 “MolCancerMed” (LSHC-CT-2004-502943) grants. Dr. L. Lacroix is acknowledged for helpful discussions and Dr. N. Saettel for the picture of quadruplex DNA.
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Communication
Engineering Bisquinolinium/Thiazole Orange Conjugates for Fluorescent Sensing of G-Quadruplex DNA†
Article first published online: 6 FEB 2009
DOI: 10.1002/anie.200805613
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Yang, P., De Cian, A., Teulade-Fichou, M.-P., Mergny, J.-L. and Monchaud, D. (2009), Engineering Bisquinolinium/Thiazole Orange Conjugates for Fluorescent Sensing of G-Quadruplex DNA. Angewandte Chemie International Edition, 48: 2188–2191. doi: 10.1002/anie.200805613
- †
Publication History
- Issue published online: 3 MAR 2009
- Article first published online: 6 FEB 2009
- Manuscript Received: 17 NOV 2008
Funded by
- ARC
- EU. Grant Number: LSHC-CT-2004-502943
Keywords:
- DNA;
- fluorescence probes;
- G-Quadruplex;
- guanine
Graphical Abstract
Lighting up: A G-quadruplex-specific fluorescent probe was designed combining the specificity of the pyridodicarboxamide motif for guanine quadruplexes and the fluorescence properties of thiazole orange. While the assembly of the two partners through a flexible linker leads to a nonselective probe, merging them in a single, rigid scaffold leads to a dye that elicits the properties required for G-quadruplex sensing.
Abstract
Lighting up: A G-quadruplex-specific fluorescent probe was designed combining the specificity of the pyridodicarboxamide motif for guanine quadruplexes and the fluorescence properties of thiazole orange. While the assembly of the two partners through a flexible linker leads to a nonselective probe, merging them in a single, rigid scaffold leads to a dye that elicits the properties required for G-quadruplex sensing.