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Duplex Stabilization and Energy Transfer in Zipper Porphyrin–DNA

Authors


  • Financial support by the EPSRC and ATDbio Southampton is greatly acknowledged. We thank Jon Burns for valuable help in the structure calculation of the porphyrin–DNA.

Abstract

Zip it up: Attachment of porphyrins onto complementary DNA strands leads to zipper-porphyrin arrays and, in the presence of eleven modifications, an increase in the melting temperature of the duplex. Mixed zinc and free-base porphyrin arrays undergo energy transfer from the zinc porphyrin to the free-base porphyrin in the annealed duplex but not in the denatured form (see scheme), giving access to reversible formation of potential photonic wires.

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