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Exploiting the Divergent Reactivity of Aryl–Palladium Intermediates for the Rapid Assembly of Fluorene and Phenanthrene Derivatives


  • We thank the Natural Sciences and Engineering Research Council (NSERC), the Merck Frosst Centre for Therapeutic Research, and the University of Toronto for financial support. B.M. thanks the Government of Ontario for a schloraship. Y.-B.Z. thanks the Government of China for a National Graduate Student Program of Building World-Class Universities Grant. D.C. thanks NSERC for a PGS M scholarship. B.L. thanks the Swiss National Science Foundation for a postdoctoral fellowship.


They all fall down: The value of domino processes can be greatly enhanced when the possibility exists for one to selectively diverge from a common intermediate. In preliminary studies the dual reactivity of aryl–palladium intermediates is exploited. A diverse array of fluorene and phenanthrene derivatives were synthesized in a rapid and efficient manner (see scheme).

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