We thank Dr. Markus Döblinger for performing TEM. Financial support from the SFB 486 (DFG) and the NIM cluster is gratefully acknowledged.
Biotin–Avidin as a Protease-Responsive Cap System for Controlled Guest Release from Colloidal Mesoporous Silica†
Article first published online: 23 MAR 2009
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 17, pages 3092–3095, April 14, 2009
How to Cite
Schlossbauer, A., Kecht, J. and Bein, T. (2009), Biotin–Avidin as a Protease-Responsive Cap System for Controlled Guest Release from Colloidal Mesoporous Silica. Angew. Chem. Int. Ed., 48: 3092–3095. doi: 10.1002/anie.200805818
- Issue published online: 7 APR 2009
- Article first published online: 23 MAR 2009
- Manuscript Received: 30 NOV 2008
- drug delivery;
- fluorescence spectroscopy;
- host–guest systems;
Tell your guests when it's time to go: When avidin caps are attached to biotinylated colloidal mesoporous silica, the four subunits of the protein avidin can each bind to a biotin moiety attached to the surface (see picture). The resulting material is a promising candidate for the design of smart detergents or drug-delivery systems. The caps can be opened to release guest molecules by controlled enzymatic hydrolysis of the protein.