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Biotin–Avidin as a Protease-Responsive Cap System for Controlled Guest Release from Colloidal Mesoporous Silica


  • We thank Dr. Markus Döblinger for performing TEM. Financial support from the SFB 486 (DFG) and the NIM cluster is gratefully acknowledged.


Tell your guests when it's time to go: When avidin caps are attached to biotinylated colloidal mesoporous silica, the four subunits of the protein avidin can each bind to a biotin moiety attached to the surface (see picture). The resulting material is a promising candidate for the design of smart detergents or drug-delivery systems. The caps can be opened to release guest molecules by controlled enzymatic hydrolysis of the protein.

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