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Coherent Activation of DNA Tweezers: A “SET–RESET” Logic System


  • The research is supported by the MOLOC EC project.


Open sesame: Aptamer–substrate complexes activate the coherent operation of two tweezers that act as a “SET–RESET” logic system. Each tweezer cycles between a fluorescent open state and a closed quenched state (Q=quencher, F=fluorophore) when triggered by adenosine monophosphate (AMP) and adenosine deaminase (AD).

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