Efficient Catalytic Promiscuity for Chemically Distinct Reactions


  • This work was supported by the EPSRC, the EU network ENDIRPRO, and a CASE studentship of the BBSRC and GlaxoSmithKline to A.B. F.H. is an ERC Starting Investigator. We thank Tony Kirby and members of the Hollfelder group for comments on the manuscript.


High catalytic proficiencies observed for the native and promiscuous reaction of the Pseudomonas aeruginosa arylsulfatase (PAS; the picture shows transition states of the two substrates with corresponding binding constants Ktx) suggest that the trade-off between high activity and tight specificity can be substantially relaxed.

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